Cargando…

KN3014, a piperidine-containing small compound, inhibits auto-secretion of IL-1β from PBMCs in a patient with Muckle–Wells syndrome

NLRP3, an intracellular pattern recognition receptor, recognizes numerous pathogens and/or its own damage-associated molecules, and forms complexes with the adaptor protein ASC. These complexes constitute the NLRP3 inflammasome, a platform for processing interleukin (IL)-1β and/or IL-18. Several NLR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaneko, Naoe, Kurata, Mie, Yamamoto, Toshihiro, Shigemura, Tomonari, Agematsu, Kazunaga, Yamazaki, Takashi, Takeda, Hiroyuki, Sawasaki, Tatsuya, Koga, Tomohiro, Kawakami, Atsushi, Yachie, Akihiro, Migita, Kiyoshi, Yoshiura, Koh-ichiro, Urano, Takeshi, Masumoto, Junya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419506/ https://www.ncbi.nlm.nih.gov/pubmed/32782316 http://dx.doi.org/10.1038/s41598-020-70513-0

Ejemplares similares

Nod2-Nodosome in a Cell-Free System: Implications in Pathogenesis and Drug Discovery for Blau Syndrome and Early-Onset Sarcoidosis
por: Iwasaki, Tomoyuki, et al.
Publicado: (2016)

Novel heterozygous C243Y A20/TNFAIP3 gene mutation is responsible for chronic inflammation in autosomal-dominant Behçet's disease
por: Shigemura, Tomonari, et al.
Publicado: (2016)

Multiple Serum Cytokine Profiling to Identify Combinational Diagnostic Biomarkers in Attacks of Familial Mediterranean Fever
por: Koga, Tomohiro, et al.
Publicado: (2016)

Juvenile onset autoinflammatory disease due to a novel mutation in TNFAIP3 (A20)
por: Sato, Shuzo, et al.
Publicado: (2018)

Familial Mediterranean fever is no longer a rare disease in Japan
por: Migita, Kiyoshi, et al.
Publicado: (2016)

Identification of Disease-Promoting HLA Class I and Protective Class II Modifiers in Japanese Patients with Familial Mediterranean Fever
por: Yasunami, Michio, et al.
Publicado: (2015)

IL-18 serum concentration is continuously elevated in typical familial Mediterranean fever with M694I mutation and can distinguish atypical type
por: Yamazaki, T, et al.
Publicado: (2015)

Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome
por: Shigemura, Tomonari, et al.
Publicado: (2011)

Applications of reconstituted inflammasomes in a cell-free system to drug discovery and elucidation of the pathogenesis of autoinflammatory diseases
por: Kaneko, Naoe, et al.
Publicado: (2017)

P816: PHARMACODYNAMIC ACTIVITY OF GEN3014 (HEXABODY-CD38) IN PATIENTS WITH MULTIPLE MYELOMA SUPPORTS ENHANCED COMPLEMENT DEPENDENT CYTOTOXICITY OF GEN3014 COMPARED TO DARATUMUMAB
por: Hiemstra, Ida H., et al.
Publicado: (2023)

Intestinal edema induced by LPS-induced endotoxemia is associated with an inflammasome adaptor ASC
por: Yamamoto, Toshihiro, et al.
Publicado: (2023)

Muckle–Wells syndrome: clinical perspectives
por: Tran, Tu-Anh
Publicado: (2017)

The role of interleukin-1 in general pathology
por: Kaneko, Naoe, et al.
Publicado: (2019)

Serum Amyloid A Induces NLRP-3-Mediated IL-1β Secretion in Neutrophils
por: Migita, Kiyoshi, et al.
Publicado: (2014)

Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system
por: Nakanishi, Ayaka, et al.
Publicado: (2018)

A large family having Muckle Wells Syndrome
por: Kilic, SS, et al.
Publicado: (2015)

Somatic NLRP3 mosaicism in Muckle-Wells syndrome
por: Gonzalez-Roca, E, et al.
Publicado: (2015)

Musculoskeletal manifestations occur predominantly in patients with later-onset familial Mediterranean fever: Data from a multicenter, prospective national cohort study in Japan
por: Endo, Yushiro, et al.
Publicado: (2018)

Inflammasome assembly is required for intracellular formation of β2-microglobulin amyloid fibrils, leading to IL-1β secretion
por: Kaneko, Naoe, et al.
Publicado: (2022)

Familial Mediterranean Fever: Genotype-Phenotype Correlations in Japanese Patients
por: Migita, Kiyoshi, et al.
Publicado: (2014)

Delayed diagnosis of Muckle-Wells syndrome – analysis of influencing factors
por: Kuemmerle-Deschner, Jasmin B, et al.
Publicado: (2012)

PW02-042 - Induction of MDSC in Muckle-Wells syndrome
por: Rieber, N, et al.
Publicado: (2013)

P02-028 - Muckle-Wells syndrome and renal transplantation
por: Kortus-Götze, B, et al.
Publicado: (2013)

PReS-FINAL-2336: Induction of MDSCS in Muckle-Wells syndrome
por: Rieber, N, et al.
Publicado: (2013)

Early detection of sensorineural hearing loss in Muckle-Wells-syndrome
por: Kuemmerle-Deschner, Jasmin B., et al.
Publicado: (2015)

KN and KN two-body physics: 2-5 GeV/c
por: Michael, C
Publicado: (1972)

Basic and clinical immunology – 3014. Pollen lipid can not stimulate iNKT cells in pollen sensitized patients
por: Fereidouni, Mohammad, et al.
Publicado: (2013)

Hypofertility in Muckle Wells syndrome and treatment with IL-1 targeting drugs
por: Meinzer, Ulrich, et al.
Publicado: (2011)

Muckle–Wells syndrome in an Indian family associated with NLRP3 mutation
por: Abdulla, MC, et al.
Publicado: (2015)

DNA double strand break repair enzymes function at multiple steps in retroviral infection
por: Sakurai, Yasuteru, et al.
Publicado: (2009)

Molecular biology of autoinflammatory diseases
por: Masumoto, Junya, et al.
Publicado: (2021)

Complete Genome Sequence of the Polysaccharide-Degrading Rumen Bacterium Pseudobutyrivibrio xylanivorans MA3014 Reveals an Incomplete Glycolytic Pathway
por: Palevich, Nikola, et al.
Publicado: (2020)

A compilation of KN reactions
por: Barash-Schmidt, Naomi, et al.
Publicado: (1969)

Veneziano model for KN scattering
por: Igi, K, et al.
Publicado: (1969)

The Contribution of SAA1 Polymorphisms to Familial Mediterranean Fever Susceptibility in the Japanese Population
por: Migita, Kiyoshi, et al.
Publicado: (2013)

Treatment of Muckle-Wells syndrome: analysis of two IL-1-blocking regimens
por: Kuemmerle-Deschner, Jasmin B, et al.
Publicado: (2013)

Erratum: Muckle–Wells syndrome in an Indian family associated with NLRP3 mutation
Publicado: (2020)

New information about the kaon-nucleon-hyperon coupling constants g(KN Sigma (1197)), g(KN Sigma (1385)) and g(KN Lambda (1405))
por: Braun, O, et al.
Publicado: (1977)

Familial case of Muckle-Wells syndrome in the Russian population: a long way to the diagnosis
por: Salugina, Svetlana O, et al.
Publicado: (2014)

FRAMEWORK COLLABORATION AGREEMENT KN 2456
por: THE EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH, (CERN), et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ul3qld7nqp9nahkgqoc13mn3d0