In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives

One major bottleneck in natural product drug development is derivatization, which is pivotal for fine tuning lead compounds. A promising solution is modifying the biosynthetic machineries of middle molecules such as macrolides. Although intense studies have established various methodologies for prot...

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Detalles Bibliográficos
Autores principales: Kudo, Kei, Hashimoto, Takuya, Hashimoto, Junko, Kozone, Ikuko, Kagaya, Noritaka, Ueoka, Reiko, Nishimura, Takehiro, Komatsu, Mamoru, Suenaga, Hikaru, Ikeda, Haruo, Shin-ya, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419507/
https://www.ncbi.nlm.nih.gov/pubmed/32782248
http://dx.doi.org/10.1038/s41467-020-17769-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419507/
https://www.ncbi.nlm.nih.gov/pubmed/32782248
http://dx.doi.org/10.1038/s41467-020-17769-2

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