Cargando…
In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives
One major bottleneck in natural product drug development is derivatization, which is pivotal for fine tuning lead compounds. A promising solution is modifying the biosynthetic machineries of middle molecules such as macrolides. Although intense studies have established various methodologies for prot...
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419507/ https://www.ncbi.nlm.nih.gov/pubmed/32782248 http://dx.doi.org/10.1038/s41467-020-17769-2 |