UTX Regulates Human Neural Differentiation and Dendritic Morphology by Resolving Bivalent Promoters

UTX, a H3K27me3 demethylase, plays an important role in mouse brain development. However, so little is known about the function of UTX in human neural differentiation and dendritic morphology. In this study, we generated UTX-null human embryonic stem cells using CRISPR/Cas9, and differentiated them...

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Detalles Bibliográficos
Autores principales: Tang, Qing-Yuan, Zhang, Shuang-Feng, Dai, Shang-Kun, Liu, Cong, Wang, Ying-Ying, Du, Hong-Zhen, Teng, Zhao-Qian, Liu, Chang-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419705/
https://www.ncbi.nlm.nih.gov/pubmed/32679064
http://dx.doi.org/10.1016/j.stemcr.2020.06.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419705/
https://www.ncbi.nlm.nih.gov/pubmed/32679064
http://dx.doi.org/10.1016/j.stemcr.2020.06.015

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