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Mechanisms of drug interactions between translation-inhibiting antibiotics

Antibiotics that interfere with translation, when combined, interact in diverse and difficult-to-predict ways. Here, we explain these interactions by “translation bottlenecks”: points in the translation cycle where antibiotics block ribosomal progression. To elucidate the underlying mechanisms of dr...

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Detalles Bibliográficos
Autores principales: Kavčič, Bor, Tkačik, Gašper, Bollenbach, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7421507/
https://www.ncbi.nlm.nih.gov/pubmed/32782250
http://dx.doi.org/10.1038/s41467-020-17734-z