Structural, in silico, and functional analysis of a Disabled-2-derived peptide for recognition of sulfatides

Disabled-2 (Dab2) is an adaptor protein that regulates the extent of platelet aggregation by two mechanisms. In the first mechanism, Dab2 intracellularly downregulates the integrin α(IIb)β(3) receptor, converting it to a low affinity state for adhesion and aggregation processes. In the second mechan...

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Detalles Bibliográficos
Autores principales: Song, Wei, Gottschalk, Carter J., Tang, Tuo-Xian, Biscardi, Andrew, Ellena, Jeffrey F., Finkielstein, Carla V., Brown, Anne M., Capelluto, Daniel G. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7421900/
https://www.ncbi.nlm.nih.gov/pubmed/32782308
http://dx.doi.org/10.1038/s41598-020-70478-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7421900/
https://www.ncbi.nlm.nih.gov/pubmed/32782308
http://dx.doi.org/10.1038/s41598-020-70478-0

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