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Repurposing of existing FDA approved drugs for Neprilysin inhibition: An in-silico study

Neprilysin (NEP) is a neutral endopeptidase with diverse physiological roles in the body. NEP's role in degradation of diverse classes of peptides such as amyloid beta, natriuretic peptide, substance P, angiotensin, endothelins, etc., is associated with pathologies of alzheimer's, kidney a...

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Detalles Bibliográficos
Autores principales: Sankhe, Runali, Rathi, Ekta, Manandhar, Suman, Kumar, Avinash, Pai, Sreedhara Ranganath K, Kini, Suvarna G, Kishore, Anoop
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422802/
https://www.ncbi.nlm.nih.gov/pubmed/32834116
http://dx.doi.org/10.1016/j.molstruc.2020.129073