Computational Approach for Rational Design of Fusion Uricase with PAS Sequences

Tumor lysis syndrome is a life-threatening condition for humans due to the lack of urate oxidase. In this study, several variants of PASylated uricase from the Aspergillus flavus species were analyzed computationally to find the appropriate fusions to solve short half-life and stability concern. The...

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Detalles Bibliográficos
Autores principales: Najjari, Abbas, Rahimi, Hamzeh, Nojoumi, Seyed Ali, Omidinia, Eskandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422847/
https://www.ncbi.nlm.nih.gov/pubmed/32832488
http://dx.doi.org/10.22088/IJMCM.BUMS.9.1.90

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422847/
https://www.ncbi.nlm.nih.gov/pubmed/32832488
http://dx.doi.org/10.22088/IJMCM.BUMS.9.1.90

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