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Computational Approach for Rational Design of Fusion Uricase with PAS Sequences
Tumor lysis syndrome is a life-threatening condition for humans due to the lack of urate oxidase. In this study, several variants of PASylated uricase from the Aspergillus flavus species were analyzed computationally to find the appropriate fusions to solve short half-life and stability concern. The...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Babol University of Medical Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422847/ https://www.ncbi.nlm.nih.gov/pubmed/32832488 http://dx.doi.org/10.22088/IJMCM.BUMS.9.1.90 |