Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency

A leading pharmacological strategy toward HIV cure requires “shock” or activation of HIV gene expression in latently infected cells with latency reversal agents (LRAs) followed by their subsequent clearance. In a screen for novel LRAs, we used fungal secondary metabolites as a source of bioactive mo...

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Detalles Bibliográficos
Autores principales: Stoszko, Mateusz, Al-Hatmi, Abdullah M. S., Skriba, Anton, Roling, Michael, Ne, Enrico, Crespo, Raquel, Mueller, Yvonne M., Najafzadeh, Mohammad Javad, Kang, Joyce, Ptackova, Renata, LeMasters, Elizabeth, Biswas, Pritha, Bertoldi, Alessia, Kan, Tsung Wai, de Crignis, Elisa, Sulc, Miroslav, Lebbink, Joyce H.G., Rokx, Casper, Verbon, Annelies, van Ijcken, Wilfred, Katsikis, Peter D., Palstra, Robert-Jan, Havlicek, Vladimir, de Hoog, Sybren, Mahmoudi, Tokameh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423394/
https://www.ncbi.nlm.nih.gov/pubmed/32851167
http://dx.doi.org/10.1126/sciadv.aba6617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423394/
https://www.ncbi.nlm.nih.gov/pubmed/32851167
http://dx.doi.org/10.1126/sciadv.aba6617

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