Characterization of a p53/miR-34a/CSF1R/STAT3 Feedback Loop in Colorectal Cancer

BACKGROUND & AIMS: The miR-34a gene is a direct target of p53 and is commonly silenced in colorectal cancer (CRC). Here we identified the receptor tyrosine kinase CSF1R as a direct miR-34a target and characterized CSF1R as an effector of p53/miR-34a-mediated CRC suppression. METHODS: Analyses of...

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Detalles Bibliográficos
Autores principales: Shi, Xiaolong, Kaller, Markus, Rokavec, Matjaz, Kirchner, Thomas, Horst, David, Hermeking, Heiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423584/
https://www.ncbi.nlm.nih.gov/pubmed/32304779
http://dx.doi.org/10.1016/j.jcmgh.2020.04.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423584/
https://www.ncbi.nlm.nih.gov/pubmed/32304779
http://dx.doi.org/10.1016/j.jcmgh.2020.04.002

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