Developmental changes in the accessible chromatin, transcriptome and Ascl1-binding correlate with the loss in Müller Glial regenerative potential

Diseases and damage to the retina lead to losses in retinal neurons and eventual visual impairment. Although the mammalian retina has no inherent regenerative capabilities, fish have robust regeneration from Müller glia (MG). Recently, we have shown that driving expression of Ascl1 in adult mouse MG...

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Detalles Bibliográficos
Autores principales: VandenBosch, Leah S., Wohl, Stefanie G., Wilken, Matthew S., Hooper, Marcus, Finkbeiner, Connor, Cox, Kristen, Chipman, Laura, Reh, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423883/
https://www.ncbi.nlm.nih.gov/pubmed/32788677
http://dx.doi.org/10.1038/s41598-020-70334-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423883/
https://www.ncbi.nlm.nih.gov/pubmed/32788677
http://dx.doi.org/10.1038/s41598-020-70334-1

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