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Tubulin islands containing slowly hydrolyzable GTP analogs regulate the mechanism and kinetics of microtubule depolymerization

Dynamic instability of microtubules is characterized by stochastically alternating phases of growth and shrinkage and is hypothesized to be controlled by the conformation and nucleotide state of tubulin dimers within the microtubule lattice. Specifically, conformation changes (compression) in the tu...

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Detalles Bibliográficos
Autores principales: Bollinger, Jonathan A., Imam, Zachary I., Stevens, Mark J., Bachand, George D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423891/
https://www.ncbi.nlm.nih.gov/pubmed/32788644
http://dx.doi.org/10.1038/s41598-020-70602-0