Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy

In autosomal dominant optic atrophy (ADOA), caused by mutations in the mitochondrial cristae biogenesis and fusion protein optic atrophy 1 (Opa1), retinal ganglion cell (RGC) dysfunction and visual loss occur by unknown mechanisms. Here, we show a role for autophagy in ADOA pathogenesis. In RGCs exp...

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Detalles Bibliográficos
Autores principales: Zaninello, Marta, Palikaras, Konstantinos, Naon, Deborah, Iwata, Keiko, Herkenne, Stephanie, Quintana-Cabrera, Ruben, Semenzato, Martina, Grespi, Francesca, Ross-Cisneros, Fred N., Carelli, Valerio, Sadun, Alfredo A., Tavernarakis, Nektarios, Scorrano, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423926/
https://www.ncbi.nlm.nih.gov/pubmed/32788597
http://dx.doi.org/10.1038/s41467-020-17821-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423926/
https://www.ncbi.nlm.nih.gov/pubmed/32788597
http://dx.doi.org/10.1038/s41467-020-17821-1

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