Cargando…

Chemical p38 MAP kinase inhibition constrains tissue inflammation and improves antibiotic activity in Mycobacterium tuberculosis-infected mice

Host-modulating therapies have become an important focus in the development of novel concepts for improved management of tuberculosis (TB). Previous in vitro studies revealed that the p38 MAP kinase signaling pathway coordinates several inflammatory and stress responses in Mycobacterium tuberculosis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hölscher, Christoph, Gräb, Jessica, Hölscher, Alexandra, Müller, Annie Linnea, Schäfer, Stephan C., Rybniker, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423948/ https://www.ncbi.nlm.nih.gov/pubmed/32788581 http://dx.doi.org/10.1038/s41598-020-70184-x

Ejemplares similares

Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages
por: Theobald, Sebastian J., et al.
Publicado: (2021)

The Expanding Role of p38 Mitogen-Activated Protein Kinase in Programmed Host Cell Death
por: Gräb, Jessica, et al.
Publicado: (2019)

Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition
por: Gräb, Jessica, et al.
Publicado: (2019)

IL-6 Is Not Absolutely Essential for the Development of a TH17 Immune Response after an Aerosol Infection with Mycobacterium tuberculosis H37rv
por: Ritter, Kristina, et al.
Publicado: (2020)

High-Dose Mycobacterium tuberculosis H37rv Infection in IL-17A- and IL-17A/F-Deficient Mice
por: Ritter, Kristina, et al.
Publicado: (2022)

IL-22 Is Mainly Produced by IFNγ-Secreting Cells but Is Dispensable for Host Protection against Mycobacterium tuberculosis Infection
por: Behrends, Jochen, et al.
Publicado: (2013)

Interleukin-23 instructs protective multifunctional CD4 T cell responses after immunization with the Mycobacterium tuberculosis subunit vaccine H1 DDA/TDB independently of interleukin-17A
por: Ritter, Kristina, et al.
Publicado: (2021)

The Role of gp130 Cytokines in Tuberculosis
por: Ritter, Kristina, et al.
Publicado: (2020)

Interleukin-27 in Tuberculosis: A Sheep in Wolf’s Clothing?
por: Ritter, Kristina, et al.
Publicado: (2022)

Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation
por: Ring, Sarah, et al.
Publicado: (2019)

In vitro Activity of Repurposed Nitroxoline Against Clinically Isolated Mycobacteria Including Multidrug-Resistant Mycobacterium tuberculosis
por: Hoffmann, Ada Marie, et al.
Publicado: (2022)

Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6
por: Hammaker, Deepa, et al.
Publicado: (2014)

No Evidence for Acquired Mutations Associated with Cytochrome bc(1) Inhibitor Resistance in 13,559 Clinical Mycobacterium tuberculosis Complex Isolates
por: Rybniker, Jan, et al.
Publicado: (2018)

Arginase-1 Is Responsible for IL-13-Mediated Susceptibility to Trypanosoma cruzi Infection
por: Abad Dar, Mahin, et al.
Publicado: (2018)

The interaction between map complexity and crowd movement on navigation decisions in virtual reality
por: Zhao, Hantao, et al.
Publicado: (2020)

During acute experimental infection with the reticulotropic Trypanosoma cruzi strain Tulahuen IL-22 is induced IL-23-dependently but is dispensable for protection
por: Erdmann, Hanna, et al.
Publicado: (2016)

A predicted operon map for Mycobacterium tuberculosis
por: Roback, P., et al.
Publicado: (2007)

Differential Modulation of the Phosphoproteome by the MAP Kinases Isoforms p38α and p38β
por: Melamed Kadosh, Dganit, et al.
Publicado: (2023)

Synthesis and Evaluation of Pyridinyltriazoles as Inhibitors of p38 MAP Kinase
por: Moallem, Seyed Adel, et al.
Publicado: (2012)

Functions of p38 MAP Kinases in the Central Nervous System
por: Asih, Prita R., et al.
Publicado: (2020)

New drug treatments show neuroprotective effects in Alzheimer's and Parkinson's diseases
por: Hölscher, Christian
Publicado: (2014)

Moving towards a more realistic concept of what constitutes Alzheimer's disease
por: Hölscher, Christian
Publicado: (2018)

Insulin Signaling Impairment in the Brain as a Risk Factor in Alzheimer’s Disease
por: Hölscher, Christian
Publicado: (2019)

Glucagon-like peptide 1 and glucose-dependent insulinotropic peptide hormones and novel receptor agonists protect synapses in Alzheimer’s and Parkinson’s diseases
por: Hölscher, Christian
Publicado: (2022)

Complete Genome Sequencing of Mycobacterium bovis SP38 and Comparative Genomics of Mycobacterium bovis and M. tuberculosis Strains
por: Zimpel, Cristina Kraemer, et al.
Publicado: (2017)

Aberrant Activation of p38 MAP Kinase-Dependent Innate Immune Responses Is Toxic to Caenorhabditis elegans
por: Cheesman, Hilary K., et al.
Publicado: (2016)

Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment
por: VanderVen, Brian C., et al.
Publicado: (2015)

Diabetic Cardiomyopathy: Does the Type of Diabetes Matter?
por: Hölscher, Maximilian E., et al.
Publicado: (2016)

Chemical Synthesis of Cell Wall Constituents of Mycobacterium tuberculosis
por: Holzheimer, Mira, et al.
Publicado: (2021)

A Chemical Proteomics Approach to Profiling the ATP-binding Proteome of Mycobacterium tuberculosis
por: Wolfe, Lisa M., et al.
Publicado: (2013)

Dietary fiber and prebiotics and the gastrointestinal microbiota
por: Holscher, Hannah D.
Publicado: (2017)

Regulation of Peripheral Inflammation by Spinal p38 MAP Kinase in Rats
por: Boyle, David L, et al.
Publicado: (2006)

The MAP Kinase p38 Is Part of Drosophila melanogaster's Circadian Clock
por: Dusik, Verena, et al.
Publicado: (2014)

Role of p38 MAP kinase in cancer stem cells and metastasis
por: Kudaravalli, Sriya, et al.
Publicado: (2022)

The role of MAP2 kinases and p38 kinase in acute murine liver injury models
por: Zhang, Jun, et al.
Publicado: (2017)

Differing Outcome of Experimental Autoimmune Encephalitis in Macrophage/Neutrophil- and T Cell-Specific gp130-Deficient Mice
por: Holz, Kristian, et al.
Publicado: (2018)

Transition bias influences the evolution of antibiotic resistance in Mycobacterium tuberculosis
por: Payne, Joshua L., et al.
Publicado: (2019)

Bioenergetic Inhibitors: Antibiotic Efficacy and Mechanisms of Action in Mycobacterium tuberculosis
por: Hasenoehrl, Erik J., et al.
Publicado: (2021)

Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide
por: Santucci, Pierre, et al.
Publicado: (2021)

The Epistatic Landscape of Antibiotic Resistance of Different Clades of Mycobacterium tuberculosis
por: Muzondiwa, Dillon, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4d64n68u1ue4s50be6mrtt86qj