Enzymatically synthesized 2′-fluoro-modified Dicer-substrate siRNA swarms against herpes simplex virus demonstrate enhanced antiviral efficacy and low cytotoxicity

Chemical modifications of small interfering (si)RNAs are used to enhance their stability and potency, and to reduce possible off-target effects, including immunogenicity. We have earlier introduced highly effective antiviral siRNA swarms against herpes simplex virus (HSV), targeting 653 bp of the es...

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Detalles Bibliográficos
Autores principales: Levanova, Alesia A., Kalke, Kiira M., Lund, Liisa M., Sipari, Nina, Sadeghi, Mohammadreza, Nyman, Marie C., Paavilainen, Henrik, Hukkanen, Veijo, Poranen, Minna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424292/
https://www.ncbi.nlm.nih.gov/pubmed/32798603
http://dx.doi.org/10.1016/j.antiviral.2020.104916

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424292/
https://www.ncbi.nlm.nih.gov/pubmed/32798603
http://dx.doi.org/10.1016/j.antiviral.2020.104916

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