Spontaneous mutations in the single TTN gene represent high tumor mutation burden

Tumor mutation burden (TMB) is an emerging biomarker, whose calculation requires targeted sequencing of many genes. We investigated if the measurement of mutation counts within a single gene is representative of TMB. Whole-exome sequencing (WES) data from the pan-cancer cohort (n = 10,224) of TCGA,...

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Detalles Bibliográficos
Autores principales: Oh, Ji-Hye, Jang, Se Jin, Kim, Jihun, Sohn, Insuk, Lee, Ji-Young, Cho, Eun Jeong, Chun, Sung-Min, Sung, Chang Ohk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424531/
https://www.ncbi.nlm.nih.gov/pubmed/32821429
http://dx.doi.org/10.1038/s41525-019-0107-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424531/
https://www.ncbi.nlm.nih.gov/pubmed/32821429
http://dx.doi.org/10.1038/s41525-019-0107-6

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