Site-Specific Lipidation of a Small-Sized Protein Binder Enhances the Antitumor Activity through Extended Blood Half-Life

[Image: see text] Protein and peptide therapeutics tend to have a short blood circulation time mainly caused by rapid clearance in kidney, leading to a low therapeutic efficacy. Here, we demonstrate that the antitumor activity of a small-sized protein binder can be significantly enhanced by prolonge...

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Detalles Bibliográficos
Autores principales: Kim, Tae Yoon, Nam, You Ree, Park, Jin Ho, Lee, Dong-Eun, Kim, Hak-Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424708/
https://www.ncbi.nlm.nih.gov/pubmed/32803073
http://dx.doi.org/10.1021/acsomega.0c02555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424708/
https://www.ncbi.nlm.nih.gov/pubmed/32803073
http://dx.doi.org/10.1021/acsomega.0c02555

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