PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Aβ42 toxicity

Alzheimer’s disease (AD) is the most common form of dementia and the most prevalent neurodegenerative disease. Genome-wide association studies have linked PICALM to AD risk. PICALM has been implicated in Aβ(42) production and turnover, but whether it plays a direct role in modulating Aβ(42) toxicity...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Yu, Yifan, Niccoli, Teresa, Ren, Ziyu, Woodling, Nathaniel S, Aleyakpo, Benjamin, Szabadkai, Gyorgy, Partridge, Linda
Format: Online Artikel Text
Sprache:English
Veröffentlicht: Oxford University Press 2020
Schlagworte:
General Article
Online Zugang:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424762/
https://www.ncbi.nlm.nih.gov/pubmed/32592479
http://dx.doi.org/10.1093/hmg/ddaa125

Online

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424762/
https://www.ncbi.nlm.nih.gov/pubmed/32592479
http://dx.doi.org/10.1093/hmg/ddaa125

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