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Development of a highly sensitive method for detection of FLT3D835Y

BACKGROUND: Acute myeloid leukemia (AML) is a malignant hematological neoplasm of myeloid progenitor cells. Mutations of FLT3 in its tyrosine kinase domain (FLT3-TKD) are found in ~ 8% of patients with AML, with D835Y as the most common substitution. This mutation activates survival signals that dri...

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Detalles Bibliográficos
Autores principales:	Guo, Yao, Sun, Honghua, Zhang, Dengyang, Zhao, Yuming, Shi, Mingxia, Yang, Ming, Xing, Shu, Fu, Xueqi, Bin, Ting, Lu, Bo, Wu, Shunjie, Xu, Xiaojun, Xu, Xuesong, Chen, Yun, Zhao, Zhizhuang Joe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424998/ https://www.ncbi.nlm.nih.gov/pubmed/32817792 http://dx.doi.org/10.1186/s40364-020-00210-7

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