Novel HDAC/Tubulin Dual Inhibitor: Design, Synthesis and Docking Studies of α-Phthalimido-Chalcone Hybrids as Potential Anticancer Agents with Apoptosis-Inducing Activity

INTRODUCTION: In order to develop novel anticancer HDAC/tubulin dual inhibitors, a novel series of α-phthalimido-substituted chalcones-based hybrids was synthesized and characterized by IR, (1)H NMR, (13)C NMR, mass spectroscopy and X-ray analysis. METHODS: All the synthesized compounds were evaluat...

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Detalles Bibliográficos
Autores principales: Mourad, Ahmed A E, Mourad, Mai A E, Jones, Peter G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425103/
https://www.ncbi.nlm.nih.gov/pubmed/32848361
http://dx.doi.org/10.2147/DDDT.S256756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425103/
https://www.ncbi.nlm.nih.gov/pubmed/32848361
http://dx.doi.org/10.2147/DDDT.S256756

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