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Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU
The mitochondrial calcium uniporter (MCU) is a calcium-activated calcium channel critical for signaling and bioenergetics. MCU, the pore-forming subunit of the uniporter, contains two transmembrane domains and is found in all major eukaryotic taxa. In amoeba and fungi, MCU homologs are sufficient to...
Autores principales: | MacEwen, Melissa JS, Markhard, Andrew L, Bozbeyoglu, Mert, Bradford, Forrest, Goldberger, Olga, Mootha, Vamsi K, Sancak, Yasemin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Life Science Alliance LLC
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425227/ https://www.ncbi.nlm.nih.gov/pubmed/32769116 http://dx.doi.org/10.26508/lsa.202000718 |
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