NVD-BM-mediated genetic biosensor triggers accumulation of 7-dehydrocholesterol and inhibits melanoma via Akt1/NF-ĸB signaling

Aberrant activation of the cholesterol biosynthesis supports tumor cell growth. In recent years, significant progress has been made by targeting rate-limiting enzymes in cholesterol biosynthesis pathways to prevent carcinogenesis. However, precise mechanisms behind cholesterol degradation in cancer...

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Detalles Bibliográficos
Autores principales: Liu, Jia, Cao, Lei, Qu, Jun-Ze, Chen, Ting-Ting, Su, Zi-Jie, Hu, Yun-Long, Wang, Ying, Yao, Ming-Dong, Xiao, Wen-Hai, Li, Chun, Li, Bo, Yuan, Ying-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425431/
https://www.ncbi.nlm.nih.gov/pubmed/32712598
http://dx.doi.org/10.18632/aging.103562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425431/
https://www.ncbi.nlm.nih.gov/pubmed/32712598
http://dx.doi.org/10.18632/aging.103562

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