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Megakaryocytes promote osteoclastogenesis in aging

Megakaryocytes (MKs) support bone formation by stimulating osteoblasts (OBs) and inhibiting osteoclasts (OCs). Aging results in higher bone resorption, leading to bone loss. Whereas previous studies showed the effects of aging on MK-mediated bone formation, the effects of aging on MK-mediated OC for...

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Detalles Bibliográficos
Autores principales: Kanagasabapathy, Deepa, Blosser, Rachel J., Maupin, Kevin A., Hong, Jung Min, Alvarez, Marta, Ghosh, Joydeep, Mohamad, Safa F., Aguilar-Perez, Alexandra, Srour, Edward F., Kacena, Melissa A., Bruzzaniti, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425434/
https://www.ncbi.nlm.nih.gov/pubmed/32634116
http://dx.doi.org/10.18632/aging.103595