Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression

Studies indicate that mutant α-synuclein (mαSyn) is involved in the pathogenesis of Parkinson’s disease (PD). The mαSyn expression leads to the loss of dopaminergic neurons in the substantia nigra (SN) and consequent motor dysfunctions. Additionally, studies found that PD was accompanied by extensiv...

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Detalles Bibliográficos
Autores principales: Wang, Yong, Wang, Qian, Yu, Ruobing, Zhang, Qi, Zhang, Zhonghai, Li, Haiying, Ren, Chao, Yang, Rongli, Niu, Haichen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425448/
https://www.ncbi.nlm.nih.gov/pubmed/32706757
http://dx.doi.org/10.18632/aging.103440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425448/
https://www.ncbi.nlm.nih.gov/pubmed/32706757
http://dx.doi.org/10.18632/aging.103440

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