MiR-185 targets POT1 to induce telomere dysfunction and cellular senescence

Protection of telomere 1 (POT1), the telomeric single-stranded DNA (ssDNA)-binding protein in the shelterin complex, has been implicated in the DNA damage response, tumorigenesis and aging. Telomere dysfunction induced by telomere deprotection could accelerate cellular senescence in primary human ce...

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Detalles Bibliográficos
Autores principales: Li, Tingting, Luo, Zhenhua, Lin, Song, Li, Chujun, Dai, Shenkun, Wang, Haoli, Huang, Junjiu, Ma, Wenbin, Songyang, Zhou, Huang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425516/
https://www.ncbi.nlm.nih.gov/pubmed/32687062
http://dx.doi.org/10.18632/aging.103541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425516/
https://www.ncbi.nlm.nih.gov/pubmed/32687062
http://dx.doi.org/10.18632/aging.103541

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