Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis

It remains unknown if biophysical or material properties of biomolecular condensates regulate cancer. Here we show that AKAP95, a nuclear protein that regulates transcription and RNA splicing, plays an important role in tumorigenesis by supporting cancer cell growth and suppressing oncogene-induced...

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Detalles Bibliográficos
Autores principales: Li, Wei, Hu, Jing, Shi, Bi, Palomba, Francesco, Digman, Michelle A., Gratton, Enrico, Jiang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425812/
https://www.ncbi.nlm.nih.gov/pubmed/32719551
http://dx.doi.org/10.1038/s41556-020-0550-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425812/
https://www.ncbi.nlm.nih.gov/pubmed/32719551
http://dx.doi.org/10.1038/s41556-020-0550-8

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