Selective enhancement of cardiomyocyte efficiency results in a pernicious heart condition

Transgenic mice with selective induction of calreticulin transgene expression in cardiomyocytes (Cardiac(CRT+)) were analyzed. Cardiac(CRT+) cardiomyocytes showed increased contractility and Ca(2+) transients. Yet, in vivo assessment of cardiac performance, and ischemic tolerance of Cardiac(CRT+) mi...

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Detalles Bibliográficos
Autores principales: Groenendyk, Jody, Wang, Qian, Wagg, Cory, Lee, Dukgyu, Robinson, Alison, Barr, Amy, Light, Peter E., Lopaschuk, Gary D., Agellon, Luis B., Michalak, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425937/
https://www.ncbi.nlm.nih.gov/pubmed/32790682
http://dx.doi.org/10.1371/journal.pone.0236457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425937/
https://www.ncbi.nlm.nih.gov/pubmed/32790682
http://dx.doi.org/10.1371/journal.pone.0236457

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