Detection of baloxavir resistant influenza A viruses using next generation sequencing and pyrosequencing methods

Baloxavir, a new antiviral drug targeting cap-dependent endonuclease activity of polymerase acidic (PA) protein of influenza viruses, is now approved in multiple countries. Several substitutions at isoleucine 38 in PA protein (e.g., PA-I38T) have been associated with decreased baloxavir susceptibili...

Descripción completa

Detalles Bibliográficos
Autores principales: Patel, Mira C., Mishin, Vasiliy P., De La Cruz, Juan A., Chesnokov, Anton, Nguyen, Ha T., Wilson, Malania M., Barnes, John, Kondor, Rebecca J.G., Wentworth, David E., Gubareva, Larisa V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426223/
https://www.ncbi.nlm.nih.gov/pubmed/32798601
http://dx.doi.org/10.1016/j.antiviral.2020.104906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426223/
https://www.ncbi.nlm.nih.gov/pubmed/32798601
http://dx.doi.org/10.1016/j.antiviral.2020.104906

Ejemplares similares