Modulation of SRSF2 expression reverses the exhaustion of TILs via the epigenetic regulation of immune checkpoint molecules

The elevated expression of immune checkpoints by the tumor microenvironment is associated with poor prognosis in several cancers due to the exhaustion of tumor-infiltrating lymphocytes (TILs), and the effective suppression of the expression of these genes is key to reversing the exhaustion of TILs....

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Detalles Bibliográficos
Autores principales: Wang, Ziqiang, Li, Kun, Chen, Wei, Wang, Xiaoxia, Huang, Yikun, Wang, Weiming, Wu, Wanjun, Cai, Zhiming, Huang, Weiren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426320/
https://www.ncbi.nlm.nih.gov/pubmed/31838573
http://dx.doi.org/10.1007/s00018-019-03362-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426320/
https://www.ncbi.nlm.nih.gov/pubmed/31838573
http://dx.doi.org/10.1007/s00018-019-03362-4

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