Isoform specific FBXW7 mediates NOTCH1 Abruptex mutation C1133Y deregulation in oral squamous cell carcinoma

Our group previously identified that the NOTCH1 Abruptex domain contains the most mutations in Chinese OSCC patients, including a hotspot mutation (C1133Y). FBXW7 is an E3 ubiquitin ligase that regulates a network of proteins, including NOTCH1, via degradation. In this study, we first described the...

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Detalles Bibliográficos
Autores principales: Zheng, Yang, Song, An, Wang, Chundi, Zhang, Wei, Liang, Dong, Ding, Xu, Li, Gang, Zhang, Hongchuang, Du, Yifei, Zhou, Junbo, Wu, Heming, Wu, Yunong, Song, Xiaomeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426429/
https://www.ncbi.nlm.nih.gov/pubmed/32792479
http://dx.doi.org/10.1038/s41419-020-02873-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426429/
https://www.ncbi.nlm.nih.gov/pubmed/32792479
http://dx.doi.org/10.1038/s41419-020-02873-4

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