Glycogen Synthase Kinase-3β Mediates Proinflammatory Cytokine Secretion and Adipogenesis in Orbital Fibroblasts from Patients with Graves’ Orbitopathy

PURPOSE: We sought to determine the role of glycogen synthase kinase-3β (GSK-3β) in the pathogenesis of Graves’ orbitopathy(GO). METHODS: Expression of the GSK-3β gene in whole orbital tissue explants was compared between GO and non-GO donors using quantitative real-time PCR (RT-PCR). The expression...

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Detalles Bibliográficos
Autores principales: Lee, Jihei Sara, Chae, Min Kyoung, Kikkawa, Don O., Lee, Eun Jig, Yoon, Jin Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Biochemistry and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426624/
https://www.ncbi.nlm.nih.gov/pubmed/32735324
http://dx.doi.org/10.1167/iovs.61.8.51

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426624/
https://www.ncbi.nlm.nih.gov/pubmed/32735324
http://dx.doi.org/10.1167/iovs.61.8.51

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