Engineering designer beta cells with a CRISPR-Cas9 conjugation platform

Genetically fusing protein domains to Cas9 has yielded several transformative technologies; however, the genetic modifications are limited to natural polypeptide chains at the Cas9 termini, which excludes a diverse array of molecules useful for gene editing. Here, we report chemical modifications th...

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Detalles Bibliográficos
Autores principales: Lim, Donghyun, Sreekanth, Vedagopuram, Cox, Kurt J., Law, Benjamin K., Wagner, Bridget K., Karp, Jeffrey M., Choudhary, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426819/
https://www.ncbi.nlm.nih.gov/pubmed/32792475
http://dx.doi.org/10.1038/s41467-020-17725-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426819/
https://www.ncbi.nlm.nih.gov/pubmed/32792475
http://dx.doi.org/10.1038/s41467-020-17725-0

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