Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis

Arrest of oligodendrocyte (OL) differentiation and remyelination following myelin damage in multiple sclerosis (MS) is associated with neurodegeneration and clinical worsening. We show that Glutathione S-transferase 4α (Gsta4) is highly expressed during adult OL differentiation and that Gsta4 loss i...

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Detalles Bibliográficos
Autores principales: Carlström, Karl E., Zhu, Keying, Ewing, Ewoud, Krabbendam, Inge E., Harris, Robert A., Falcão, Ana Mendanha, Jagodic, Maja, Castelo-Branco, Gonçalo, Piehl, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426940/
https://www.ncbi.nlm.nih.gov/pubmed/32792491
http://dx.doi.org/10.1038/s41467-020-17871-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426940/
https://www.ncbi.nlm.nih.gov/pubmed/32792491
http://dx.doi.org/10.1038/s41467-020-17871-5

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