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Antibody-protein binding and conformational changes: identifying allosteric signalling pathways to engineer a better effector response
Numerous monoclonal antibodies have been developed successfully for the treatment of various diseases. Nevertheless, the development of biotherapeutic antibodies is complex, expensive, and time-consuming, and to facilitate this process, careful structural analysis beyond the antibody binding site is...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426963/ https://www.ncbi.nlm.nih.gov/pubmed/32792612 http://dx.doi.org/10.1038/s41598-020-70680-0 |