Cargando…
Antibody-protein binding and conformational changes: identifying allosteric signalling pathways to engineer a better effector response
Numerous monoclonal antibodies have been developed successfully for the treatment of various diseases. Nevertheless, the development of biotherapeutic antibodies is complex, expensive, and time-consuming, and to facilitate this process, careful structural analysis beyond the antibody binding site is...
Autores principales: | Al Qaraghuli, Mohammed M., Kubiak-Ossowska, Karina, Ferro, Valerie A., Mulheran, Paul A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426963/ https://www.ncbi.nlm.nih.gov/pubmed/32792612 http://dx.doi.org/10.1038/s41598-020-70680-0 |
Ejemplares similares
-
Structural Analysis of Anti-Hapten Antibodies to Identify Long-Range Structural Movements Induced by Hapten Binding
por: Al Qaraghuli, Mohammed M., et al.
Publicado: (2021) -
Thinking outside the Laboratory: Analyses of Antibody Structure and Dynamics within Different Solvent Environments in Molecular Dynamics (MD) Simulations
por: Al Qaraghuli, Mohammed M., et al.
Publicado: (2018) -
Biomolecular interactions with nanoparticles: applications for coronavirus disease 2019
por: Farouq, Mohammed A.H., et al.
Publicado: (2021) -
Functionalisation of Inorganic Material Surfaces with Staphylococcus Protein A: A Molecular Dynamics Study
por: Farouq, Mohammed A. H., et al.
Publicado: (2022) -
Chitin and Chitosan
Binding to the α-Chitin
Crystal: A Molecular Dynamics Study
por: Hudek, Magdalena, et al.
Publicado: (2023)