Hederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells

Autophagy inhibition has been demonstrated to increase the efficacy of conventional chemotherapy. In this study, we identified hederagenin, a triterpenoid derived from Hedera helix, as a potent inhibitor of autophagy and then hypothesized that hederagenin might synergize with chemotherapeutic drugs...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Kun, Liu, Xiaodong, Liu, Quanmeng, Ho, Idy ht, Wei, Xianli, Yin, Ting, Zhan, Yujuan, Zhang, Wenjing, Zhang, Wenbo, Chen, Bonan, Gu, Jiangyong, Tan, Yuhui, Zhang, Lin, Chan, Matthew Tv, Wu, William Kk, Du, Biaoyan, Xiao, Jianyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426971/
https://www.ncbi.nlm.nih.gov/pubmed/32792495
http://dx.doi.org/10.1038/s41419-020-02880-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426971/
https://www.ncbi.nlm.nih.gov/pubmed/32792495
http://dx.doi.org/10.1038/s41419-020-02880-5

Ejemplares similares