Revising the mechanism of p75NTR activation: intrinsically monomeric state of death domains invokes the "helper" hypothesis

The neurotrophin receptor p75NTR plays crucial roles in neuron development and regulates important neuronal processes like degeneration, apoptosis and cell survival. At the same time the detailed mechanism of signal transduction is unclear. One of the main hypotheses known as the snail-tong mechanis...

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Detalles Bibliográficos
Autores principales: Goncharuk, Sergey A., Artemieva, Lilya E., Nadezhdin, Kirill D., Arseniev, Alexander S., Mineev, Konstantin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427093/
https://www.ncbi.nlm.nih.gov/pubmed/32792564
http://dx.doi.org/10.1038/s41598-020-70721-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427093/
https://www.ncbi.nlm.nih.gov/pubmed/32792564
http://dx.doi.org/10.1038/s41598-020-70721-8

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