Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15

New therapeutics are urgently needed to inhibit SARS-CoV-2, the virus responsible for the ongoing Covid-19 pandemic. Nsp15, a uridine-specific endoribonuclease found in all coronaviruses, processes viral RNA to evade detection by RNA-activated host defense systems, making it a promising drug target....

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Detalles Bibliográficos
Autores principales: Pillon, Monica C., Frazier, Meredith N., Dillard, Lucas B., Williams, Jason G., Kocaman, Seda, Krahn, Juno M., Perera, Lalith, Hayne, Cassandra K., Gordon, Jacob, Stewart, Zachary D., Sobhany, Mack, Deterding, Leesa J., Hsu, Allen L., Dandey, Venkata P., Borgnia, Mario J., Stanley, Robin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427136/
https://www.ncbi.nlm.nih.gov/pubmed/32803198
http://dx.doi.org/10.1101/2020.08.11.244863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427136/
https://www.ncbi.nlm.nih.gov/pubmed/32803198
http://dx.doi.org/10.1101/2020.08.11.244863

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