Nascent Transcript Folding Plays a Major Role in Determining RNA Polymerase Elongation Rates

Transcription elongation rates influence RNA processing, but sequence-specific regulation is poorly understood. We addressed this in vivo, analyzing RNAPI in S. cerevisiae. Mapping RNAPI by Miller chromatin spreads or UV crosslinking revealed 5′ enrichment and strikingly uneven local polymerase occu...

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Detalles Bibliográficos
Autores principales: Turowski, Tomasz W., Petfalski, Elisabeth, Goddard, Benjamin D., French, Sarah L., Helwak, Aleksandra, Tollervey, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427326/
https://www.ncbi.nlm.nih.gov/pubmed/32585128
http://dx.doi.org/10.1016/j.molcel.2020.06.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427326/
https://www.ncbi.nlm.nih.gov/pubmed/32585128
http://dx.doi.org/10.1016/j.molcel.2020.06.002

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