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Nascent Transcript Folding Plays a Major Role in Determining RNA Polymerase Elongation Rates
Transcription elongation rates influence RNA processing, but sequence-specific regulation is poorly understood. We addressed this in vivo, analyzing RNAPI in S. cerevisiae. Mapping RNAPI by Miller chromatin spreads or UV crosslinking revealed 5′ enrichment and strikingly uneven local polymerase occu...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427326/ https://www.ncbi.nlm.nih.gov/pubmed/32585128 http://dx.doi.org/10.1016/j.molcel.2020.06.002 |