Interleukin-27 Functional Duality Balances Leishmania Infectivity and Pathogenesis

IL-27 is a cytokine that exerts diverse effects on the cells of innate and adaptive immune systems. Chiefly expressed in macrophages and dendritic cells during the early phase of Leishmania infection, IL-27 contributes to the protection against L. major infection but suppresses the protective Th1 re...

Descripción completa

Detalles Bibliográficos
Autores principales: Jafarzadeh, Abdollah, Nemati, Maryam, Chauhan, Prashant, Patidar, Ashok, Sarkar, Arup, Sharifi, Iraj, Saha, Bhaskar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427467/
https://www.ncbi.nlm.nih.gov/pubmed/32849534
http://dx.doi.org/10.3389/fimmu.2020.01573
_version_ 1783570883384705024
author Jafarzadeh, Abdollah
Nemati, Maryam
Chauhan, Prashant
Patidar, Ashok
Sarkar, Arup
Sharifi, Iraj
Saha, Bhaskar
author_facet Jafarzadeh, Abdollah
Nemati, Maryam
Chauhan, Prashant
Patidar, Ashok
Sarkar, Arup
Sharifi, Iraj
Saha, Bhaskar
author_sort Jafarzadeh, Abdollah
collection PubMed
description IL-27 is a cytokine that exerts diverse effects on the cells of innate and adaptive immune systems. Chiefly expressed in macrophages and dendritic cells during the early phase of Leishmania infection, IL-27 contributes to the protection against L. major infection but suppresses the protective Th1 response against L. donovani, L. infantum, L. amazonensis and L. braziliensis infections, suggesting its functional duality. During the late stage of Leishmania infection, IL-27 limits the immunopathogenic reactions and tissue damages. Herein, we analyze the mechanism of the functional duality of IL-27 in the resistance or susceptibility to Leishmania infection, prompting IL-27 for anti-Leishmanial therapy.
format Online
Article
Text
id pubmed-7427467
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-74274672020-08-25 Interleukin-27 Functional Duality Balances Leishmania Infectivity and Pathogenesis Jafarzadeh, Abdollah Nemati, Maryam Chauhan, Prashant Patidar, Ashok Sarkar, Arup Sharifi, Iraj Saha, Bhaskar Front Immunol Immunology IL-27 is a cytokine that exerts diverse effects on the cells of innate and adaptive immune systems. Chiefly expressed in macrophages and dendritic cells during the early phase of Leishmania infection, IL-27 contributes to the protection against L. major infection but suppresses the protective Th1 response against L. donovani, L. infantum, L. amazonensis and L. braziliensis infections, suggesting its functional duality. During the late stage of Leishmania infection, IL-27 limits the immunopathogenic reactions and tissue damages. Herein, we analyze the mechanism of the functional duality of IL-27 in the resistance or susceptibility to Leishmania infection, prompting IL-27 for anti-Leishmanial therapy. Frontiers Media S.A. 2020-08-07 /pmc/articles/PMC7427467/ /pubmed/32849534 http://dx.doi.org/10.3389/fimmu.2020.01573 Text en Copyright © 2020 Jafarzadeh, Nemati, Chauhan, Patidar, Sarkar, Sharifi and Saha. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Jafarzadeh, Abdollah
Nemati, Maryam
Chauhan, Prashant
Patidar, Ashok
Sarkar, Arup
Sharifi, Iraj
Saha, Bhaskar
Interleukin-27 Functional Duality Balances Leishmania Infectivity and Pathogenesis
title Interleukin-27 Functional Duality Balances Leishmania Infectivity and Pathogenesis
title_full Interleukin-27 Functional Duality Balances Leishmania Infectivity and Pathogenesis
title_fullStr Interleukin-27 Functional Duality Balances Leishmania Infectivity and Pathogenesis
title_full_unstemmed Interleukin-27 Functional Duality Balances Leishmania Infectivity and Pathogenesis
title_short Interleukin-27 Functional Duality Balances Leishmania Infectivity and Pathogenesis
title_sort interleukin-27 functional duality balances leishmania infectivity and pathogenesis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427467/
https://www.ncbi.nlm.nih.gov/pubmed/32849534
http://dx.doi.org/10.3389/fimmu.2020.01573
work_keys_str_mv AT jafarzadehabdollah interleukin27functionaldualitybalancesleishmaniainfectivityandpathogenesis
AT nematimaryam interleukin27functionaldualitybalancesleishmaniainfectivityandpathogenesis
AT chauhanprashant interleukin27functionaldualitybalancesleishmaniainfectivityandpathogenesis
AT patidarashok interleukin27functionaldualitybalancesleishmaniainfectivityandpathogenesis
AT sarkararup interleukin27functionaldualitybalancesleishmaniainfectivityandpathogenesis
AT sharifiiraj interleukin27functionaldualitybalancesleishmaniainfectivityandpathogenesis
AT sahabhaskar interleukin27functionaldualitybalancesleishmaniainfectivityandpathogenesis

Ejemplares similares