Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing

Hematopoietic ageing involves declining erythropoiesis and lymphopoiesis, leading to frequent anaemia and decreased adaptive immunity. How intrinsic changes to the hematopoietic stem cells (HSCs), an altered microenvironment and systemic factors contribute to this process is not fully understood. He...

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Detalles Bibliográficos
Autores principales: Valletta, Simona, Thomas, Alexander, Meng, Yiran, Ren, Xiying, Drissen, Roy, Sengül, Hilal, Di Genua, Cristina, Nerlov, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427787/
https://www.ncbi.nlm.nih.gov/pubmed/32796847
http://dx.doi.org/10.1038/s41467-020-17942-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427787/
https://www.ncbi.nlm.nih.gov/pubmed/32796847
http://dx.doi.org/10.1038/s41467-020-17942-7

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