CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid

hnRNPA2 is a human ribonucleoprotein (RNP) involved in RNA metabolism. It forms fibrils both under cellular stress and in mutated form in neurodegenerative conditions. Previous work established that the C-terminal low-complexity domain (LCD) of hnRNPA2 fibrillizes under stress, and missense mutation...

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Detalles Bibliográficos
Autores principales: Lu, Jiahui, Cao, Qin, Hughes, Michael P., Sawaya, Michael R., Boyer, David R., Cascio, Duilio, Eisenberg, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427792/
https://www.ncbi.nlm.nih.gov/pubmed/32796831
http://dx.doi.org/10.1038/s41467-020-17905-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427792/
https://www.ncbi.nlm.nih.gov/pubmed/32796831
http://dx.doi.org/10.1038/s41467-020-17905-y

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