Cargando…

Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A(2) and inflammatory cytokines in patients referred for coronary angiography

BACKGROUND: The potential cardioprotective benefits of olive oil (OO) and canola oil (CO) consumption have been shown in some studies. The present study compared the effects of CO and OO on plasma lipids, some inflammatory cytokines, and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) mass and...

Descripción completa

Detalles Bibliográficos
Autores principales: Khandouzi, Nafiseh, Zahedmehr, Ali, Nasrollahzadeh, Javad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427979/
https://www.ncbi.nlm.nih.gov/pubmed/32795310
http://dx.doi.org/10.1186/s12944-020-01362-z
_version_ 1783570988212944896
author Khandouzi, Nafiseh
Zahedmehr, Ali
Nasrollahzadeh, Javad
author_facet Khandouzi, Nafiseh
Zahedmehr, Ali
Nasrollahzadeh, Javad
author_sort Khandouzi, Nafiseh
collection PubMed
description BACKGROUND: The potential cardioprotective benefits of olive oil (OO) and canola oil (CO) consumption have been shown in some studies. The present study compared the effects of CO and OO on plasma lipids, some inflammatory cytokines, and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) mass and activity in patients undergoing coronary angiography. METHODS: The current randomized, controlled, parallel-arm, clinical trial involved 48 patients (44 men and 4 women, aged 57.63 ± 6.34 years) with at least one classic cardiovascular risk factor (hypertension, dyslipidemia, or diabetes) who referred for coronary angiography. Patients were randomly divided into two groups and received 25 mL/day refined olive oil (n = 24) or canola oil (n = 24) for 6 weeks. Plasma lipids, some selected inflammatory markers, and Lp-PLA(2) levels were measured at baseline and after the intervention. RESULTS: CO consumption produced a significant reduction in plasma Lp-PLA(2) mass (− 0.97 ± 1.84 vs. 0.34 ± 1.57 ng/mL, p = 0.008 for CO and OO, respectively), whereas the mean changes in interleukine-6 concentration were significantly lower after OO consumption compared with CO (− 9.46 ± 9.46 vs. -0.90 ± 6.80 pg/mL, p = 0.008 for OO and CO, respectively). After 6 weeks of intervention, no significant changes were observed in plasma Lp-PLA(2) activity, complement C3, C4, or lipid profiles in the two intervention groups. CONCLUSIONS: Comparing the two vegetable oils in subjects with cardiovascular risk factors showed that the consumption of olive oil is more effective in reducing the level of inflammatory cytokine interleukine-6, whereas canola oil was more effective in lowering Lp-PLA(2) levels; however, this finding should be interpreted with caution, because Lp-PLA(2) activity did not change significantly. TRIAL REGISTRATION: IRCT20160702028742N5 at www.irct.ir (04/19/2019).
format Online
Article
Text
id pubmed-7427979
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-74279792020-08-17 Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A(2) and inflammatory cytokines in patients referred for coronary angiography Khandouzi, Nafiseh Zahedmehr, Ali Nasrollahzadeh, Javad Lipids Health Dis Research BACKGROUND: The potential cardioprotective benefits of olive oil (OO) and canola oil (CO) consumption have been shown in some studies. The present study compared the effects of CO and OO on plasma lipids, some inflammatory cytokines, and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) mass and activity in patients undergoing coronary angiography. METHODS: The current randomized, controlled, parallel-arm, clinical trial involved 48 patients (44 men and 4 women, aged 57.63 ± 6.34 years) with at least one classic cardiovascular risk factor (hypertension, dyslipidemia, or diabetes) who referred for coronary angiography. Patients were randomly divided into two groups and received 25 mL/day refined olive oil (n = 24) or canola oil (n = 24) for 6 weeks. Plasma lipids, some selected inflammatory markers, and Lp-PLA(2) levels were measured at baseline and after the intervention. RESULTS: CO consumption produced a significant reduction in plasma Lp-PLA(2) mass (− 0.97 ± 1.84 vs. 0.34 ± 1.57 ng/mL, p = 0.008 for CO and OO, respectively), whereas the mean changes in interleukine-6 concentration were significantly lower after OO consumption compared with CO (− 9.46 ± 9.46 vs. -0.90 ± 6.80 pg/mL, p = 0.008 for OO and CO, respectively). After 6 weeks of intervention, no significant changes were observed in plasma Lp-PLA(2) activity, complement C3, C4, or lipid profiles in the two intervention groups. CONCLUSIONS: Comparing the two vegetable oils in subjects with cardiovascular risk factors showed that the consumption of olive oil is more effective in reducing the level of inflammatory cytokine interleukine-6, whereas canola oil was more effective in lowering Lp-PLA(2) levels; however, this finding should be interpreted with caution, because Lp-PLA(2) activity did not change significantly. TRIAL REGISTRATION: IRCT20160702028742N5 at www.irct.ir (04/19/2019). BioMed Central 2020-08-14 /pmc/articles/PMC7427979/ /pubmed/32795310 http://dx.doi.org/10.1186/s12944-020-01362-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Khandouzi, Nafiseh
Zahedmehr, Ali
Nasrollahzadeh, Javad
Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A(2) and inflammatory cytokines in patients referred for coronary angiography
title Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A(2) and inflammatory cytokines in patients referred for coronary angiography
title_full Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A(2) and inflammatory cytokines in patients referred for coronary angiography
title_fullStr Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A(2) and inflammatory cytokines in patients referred for coronary angiography
title_full_unstemmed Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A(2) and inflammatory cytokines in patients referred for coronary angiography
title_short Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A(2) and inflammatory cytokines in patients referred for coronary angiography
title_sort effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase a(2) and inflammatory cytokines in patients referred for coronary angiography
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427979/
https://www.ncbi.nlm.nih.gov/pubmed/32795310
http://dx.doi.org/10.1186/s12944-020-01362-z
work_keys_str_mv AT khandouzinafiseh effectsofcanolaoroliveoilonplasmalipidslipoproteinassociatedphospholipasea2andinflammatorycytokinesinpatientsreferredforcoronaryangiography
AT zahedmehrali effectsofcanolaoroliveoilonplasmalipidslipoproteinassociatedphospholipasea2andinflammatorycytokinesinpatientsreferredforcoronaryangiography
AT nasrollahzadehjavad effectsofcanolaoroliveoilonplasmalipidslipoproteinassociatedphospholipasea2andinflammatorycytokinesinpatientsreferredforcoronaryangiography