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Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A(2) and inflammatory cytokines in patients referred for coronary angiography
BACKGROUND: The potential cardioprotective benefits of olive oil (OO) and canola oil (CO) consumption have been shown in some studies. The present study compared the effects of CO and OO on plasma lipids, some inflammatory cytokines, and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) mass and...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427979/ https://www.ncbi.nlm.nih.gov/pubmed/32795310 http://dx.doi.org/10.1186/s12944-020-01362-z |
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author | Khandouzi, Nafiseh Zahedmehr, Ali Nasrollahzadeh, Javad |
author_facet | Khandouzi, Nafiseh Zahedmehr, Ali Nasrollahzadeh, Javad |
author_sort | Khandouzi, Nafiseh |
collection | PubMed |
description | BACKGROUND: The potential cardioprotective benefits of olive oil (OO) and canola oil (CO) consumption have been shown in some studies. The present study compared the effects of CO and OO on plasma lipids, some inflammatory cytokines, and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) mass and activity in patients undergoing coronary angiography. METHODS: The current randomized, controlled, parallel-arm, clinical trial involved 48 patients (44 men and 4 women, aged 57.63 ± 6.34 years) with at least one classic cardiovascular risk factor (hypertension, dyslipidemia, or diabetes) who referred for coronary angiography. Patients were randomly divided into two groups and received 25 mL/day refined olive oil (n = 24) or canola oil (n = 24) for 6 weeks. Plasma lipids, some selected inflammatory markers, and Lp-PLA(2) levels were measured at baseline and after the intervention. RESULTS: CO consumption produced a significant reduction in plasma Lp-PLA(2) mass (− 0.97 ± 1.84 vs. 0.34 ± 1.57 ng/mL, p = 0.008 for CO and OO, respectively), whereas the mean changes in interleukine-6 concentration were significantly lower after OO consumption compared with CO (− 9.46 ± 9.46 vs. -0.90 ± 6.80 pg/mL, p = 0.008 for OO and CO, respectively). After 6 weeks of intervention, no significant changes were observed in plasma Lp-PLA(2) activity, complement C3, C4, or lipid profiles in the two intervention groups. CONCLUSIONS: Comparing the two vegetable oils in subjects with cardiovascular risk factors showed that the consumption of olive oil is more effective in reducing the level of inflammatory cytokine interleukine-6, whereas canola oil was more effective in lowering Lp-PLA(2) levels; however, this finding should be interpreted with caution, because Lp-PLA(2) activity did not change significantly. TRIAL REGISTRATION: IRCT20160702028742N5 at www.irct.ir (04/19/2019). |
format | Online Article Text |
id | pubmed-7427979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-74279792020-08-17 Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A(2) and inflammatory cytokines in patients referred for coronary angiography Khandouzi, Nafiseh Zahedmehr, Ali Nasrollahzadeh, Javad Lipids Health Dis Research BACKGROUND: The potential cardioprotective benefits of olive oil (OO) and canola oil (CO) consumption have been shown in some studies. The present study compared the effects of CO and OO on plasma lipids, some inflammatory cytokines, and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) mass and activity in patients undergoing coronary angiography. METHODS: The current randomized, controlled, parallel-arm, clinical trial involved 48 patients (44 men and 4 women, aged 57.63 ± 6.34 years) with at least one classic cardiovascular risk factor (hypertension, dyslipidemia, or diabetes) who referred for coronary angiography. Patients were randomly divided into two groups and received 25 mL/day refined olive oil (n = 24) or canola oil (n = 24) for 6 weeks. Plasma lipids, some selected inflammatory markers, and Lp-PLA(2) levels were measured at baseline and after the intervention. RESULTS: CO consumption produced a significant reduction in plasma Lp-PLA(2) mass (− 0.97 ± 1.84 vs. 0.34 ± 1.57 ng/mL, p = 0.008 for CO and OO, respectively), whereas the mean changes in interleukine-6 concentration were significantly lower after OO consumption compared with CO (− 9.46 ± 9.46 vs. -0.90 ± 6.80 pg/mL, p = 0.008 for OO and CO, respectively). After 6 weeks of intervention, no significant changes were observed in plasma Lp-PLA(2) activity, complement C3, C4, or lipid profiles in the two intervention groups. CONCLUSIONS: Comparing the two vegetable oils in subjects with cardiovascular risk factors showed that the consumption of olive oil is more effective in reducing the level of inflammatory cytokine interleukine-6, whereas canola oil was more effective in lowering Lp-PLA(2) levels; however, this finding should be interpreted with caution, because Lp-PLA(2) activity did not change significantly. TRIAL REGISTRATION: IRCT20160702028742N5 at www.irct.ir (04/19/2019). BioMed Central 2020-08-14 /pmc/articles/PMC7427979/ /pubmed/32795310 http://dx.doi.org/10.1186/s12944-020-01362-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Khandouzi, Nafiseh Zahedmehr, Ali Nasrollahzadeh, Javad Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A(2) and inflammatory cytokines in patients referred for coronary angiography |
title | Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A(2) and inflammatory cytokines in patients referred for coronary angiography |
title_full | Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A(2) and inflammatory cytokines in patients referred for coronary angiography |
title_fullStr | Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A(2) and inflammatory cytokines in patients referred for coronary angiography |
title_full_unstemmed | Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A(2) and inflammatory cytokines in patients referred for coronary angiography |
title_short | Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A(2) and inflammatory cytokines in patients referred for coronary angiography |
title_sort | effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase a(2) and inflammatory cytokines in patients referred for coronary angiography |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427979/ https://www.ncbi.nlm.nih.gov/pubmed/32795310 http://dx.doi.org/10.1186/s12944-020-01362-z |
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