BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage

Proper chromatin function and maintenance of genomic stability depends on spatiotemporal coordination between the transcription and replication machinery. Loss of this coordination can lead to DNA damage from increased transcription-replication collision events. We report that deregulated transcript...

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Detalles Bibliográficos
Autores principales: Lam, Fred C., Kong, Yi Wen, Huang, Qiuying, Vu Han, Tu-Lan, Maffa, Amanda D., Kasper, Ekkehard M., Yaffe, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428008/
https://www.ncbi.nlm.nih.gov/pubmed/32796829
http://dx.doi.org/10.1038/s41467-020-17503-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428008/
https://www.ncbi.nlm.nih.gov/pubmed/32796829
http://dx.doi.org/10.1038/s41467-020-17503-y

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