Cargando…
BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage
Proper chromatin function and maintenance of genomic stability depends on spatiotemporal coordination between the transcription and replication machinery. Loss of this coordination can lead to DNA damage from increased transcription-replication collision events. We report that deregulated transcript...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428008/ https://www.ncbi.nlm.nih.gov/pubmed/32796829 http://dx.doi.org/10.1038/s41467-020-17503-y |