Cargando…

Optical Control of Sphingosine-1-Phosphate Formation and Function

Sphingosine-1-phosphate (S1P) plays important roles as a signaling lipid in a variety of physiological and pathophysiological processes. S1P signals via a family of G protein-coupled receptors (S1P(1–5)) and intracellular targets. Here, we report on photoswitchable analogs of S1P and its precursor s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morstein, Johannes, Hill, Rose Z., Novak, Alexander J. E., Feng, Suihan, Norman, Derek D., Donthamsetti, Prashant C., Frank, James A., Harayama, Takeshi, Williams, Benjamin M., Parrill, Abby L., Tigyi, Gabor J., Riezman, Howard, Isacoff, Ehud Y., Bautista, Diana M., Trauner, Dirk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428055/ https://www.ncbi.nlm.nih.gov/pubmed/31036923 http://dx.doi.org/10.1038/s41589-019-0269-7

Ejemplares similares

Lysosome-targeted photoactivation reveals local sphingosine metabolism signatures
por: Feng, Suihan, et al.
Publicado: (2018)

Mitochondria-specific photoactivation to monitor local sphingosine metabolism and function
por: Feng, Suihan, et al.
Publicado: (2018)

Selective Photoswitchable Allosteric Agonist of a G Protein-Coupled Receptor
por: Donthamsetti, Prashant, et al.
Publicado: (2021)

Optical Control of Dopamine D2-like Receptors with Cell-Specific Fast-Relaxing Photoswitches
por: Hetzler, Belinda E., et al.
Publicado: (2023)

Cell specific photoswitchable agonist for reversible control of endogenous dopamine receptors
por: Donthamsetti, Prashant, et al.
Publicado: (2021)

Detection of genome-edited mutant clones by a simple competition-based PCR method
por: Harayama, Takeshi, et al.
Publicado: (2017)

The signaling lipid sphingosine 1-phosphate regulates mechanical pain
por: Hill, Rose Z, et al.
Publicado: (2018)

An organelle-specific photoactivation and dual-isotope labeling strategy reveals phosphatidylethanolamine metabolic flux
por: Simon, Clémence, et al.
Publicado: (2023)

Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer
por: Xu, Guangmeng, et al.
Publicado: (2021)

GPCR Conformations: Implications for Rational Drug Design
por: Parrill, Abby L., et al.
Publicado: (2010)

Structure and conserved function of iso-branched sphingoid bases from the nematode Caenorhabditis elegans
por: Hannich, J. Thomas, et al.
Publicado: (2017)

Vacuole-Specific Lipid Release for Tracking Intracellular Lipid Metabolism and Transport in Saccharomyces cerevisiae
por: Girik, Vladimir, et al.
Publicado: (2022)

The Role of Sphingolipids and Sphingosine-1-phosphate—Sphingosine-1-phosphate-receptor Signaling in Psoriasis
por: Masuda-Kuroki, Kana, et al.
Publicado: (2023)

Sphingosine-1-Phosphate Enhances α(1)-Adrenergic Vasoconstriction via S1P2–G(12/13)–ROCK Mediated Signaling
por: Panta, Cecília R., et al.
Publicado: (2019)

Sphingosine 1-Phosphate and Atherosclerosis
por: Kurano, Makoto, et al.
Publicado: (2018)

Intracellular sphingosine releases calcium from lysosomes
por: Höglinger, Doris, et al.
Publicado: (2015)

Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer
por: Bao, Yonghua, et al.
Publicado: (2017)

Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease
por: Ceccom, Johnatan, et al.
Publicado: (2014)

Fixing a Photosensitizer Unlocks and Localizes Its Lethality
por: Trauner, Dirk, et al.
Publicado: (2019)

Dihydro-sphingosine 1-phosphate interacts with carrier proteins in a manner distinct from that of sphingosine 1-phosphate
por: Mishima, Yuko, et al.
Publicado: (2018)

Irisin Is Target of Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor-Mediated Signaling in Skeletal Muscle Cells
por: Pierucci, Federica, et al.
Publicado: (2023)

Sphingosine Kinases/Sphingosine-1-Phosphate and Death Signalling in APP-Transfected Cells
por: Gassowska, Magdalena, et al.
Publicado: (2014)

Characterizing Sphingosine Kinases and Sphingosine 1-Phosphate Receptors in the Mammalian Eye and Retina
por: Porter, Hunter, et al.
Publicado: (2018)

Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System
por: Cannavo, Alessandro, et al.
Publicado: (2017)

Sphingosine‐1‐phosphate improves outcome of no‐reflow acute myocardial infarction via sphingosine‐1‐phosphate receptor 1
por: Polzin, Amin, et al.
Publicado: (2022)

Commentary: The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension
por: Bhavanam, Naga P., et al.
Publicado: (2015)

Flotillin proteins recruit sphingosine to membranes and maintain cellular sphingosine-1-phosphate levels
por: Riento, Kirsi, et al.
Publicado: (2018)

Impairment of Angiogenic Sphingosine Kinase-1/Sphingosine-1-Phosphate Receptors Pathway in Preeclampsia
por: Dobierzewska, Aneta, et al.
Publicado: (2016)

Targeting sphingosine-1-phosphate for cancer therapy
por: Sabbadini, R A
Publicado: (2006)

Immunological Function of Sphingosine 1-Phosphate in the Intestine
por: Kunisawa, Jun, et al.
Publicado: (2012)

Plasma Sphingosine-1-Phosphate Is Elevated in Obesity
por: Kowalski, Greg M., et al.
Publicado: (2013)

Sphingosine 1-Phosphate in Acute Dengue Infection
por: Gomes, Laksiri, et al.
Publicado: (2014)

Sphingosine 1-Phosphate signaling controls mitosis
por: Cuvillier, Olivier, et al.
Publicado: (2017)

Roles of sphingosine-1-phosphate signaling in cancer
por: Wang, Peng, et al.
Publicado: (2019)

Ceramide and Sphingosine 1-Phosphate in Liver Diseases
por: Park, Woo-Jae, et al.
Publicado: (2020)

Neurological Consequences of Sphingosine Phosphate Lyase Insufficiency
por: Atreya, Krishan B., et al.
Publicado: (2022)

Sphingosine-1-Phosphate Signaling in Cardiovascular Diseases
por: Wang, Na, et al.
Publicado: (2023)

Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3
por: Li, Chao, et al.
Publicado: (2015)

Deficiency of sphingosine-1-phosphate receptor 3 does not affect the skeletal phenotype of mice lacking sphingosine-1-phosphate lyase
por: Heckt, Timo, et al.
Publicado: (2019)

Implication of Ceramide, Ceramide 1-Phosphate and Sphingosine 1-Phosphate in Tumorigenesis
por: Gangoiti, Patricia, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_0ntsmq76b06dvd5kcosjtc4bvb