Effect size estimates from umbrella designs: Handling patients with a positive test result for multiple biomarkers using random or pragmatic subtrial allocation

Umbrella trials have been suggested to increase trial conduct efficiency when investigating different biomarker-driven experimental therapies. An overarching platform is used for patient screening and subsequent subtrial allocation according to patients’ biomarker status. Two subtrial allocation sch...

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Detalles Bibliográficos
Autores principales: Kesselmeier, Miriam, Benda, Norbert, Scherag, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428134/
https://www.ncbi.nlm.nih.gov/pubmed/32797088
http://dx.doi.org/10.1371/journal.pone.0237441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428134/
https://www.ncbi.nlm.nih.gov/pubmed/32797088
http://dx.doi.org/10.1371/journal.pone.0237441

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