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Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations
ZnT8 is a Zn(2+)/H(+) antiporter that belongs to SLC30 family and plays an essential role in regulating Zn(2+) accumulation in the insulin secretory granules of pancreatic β cells. However, the Zn(2+)/H(+) exchange mechanism of ZnT8 remains unclear due to the lack of high-resolution structures. Here...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428307/ https://www.ncbi.nlm.nih.gov/pubmed/32723473 http://dx.doi.org/10.7554/eLife.58823 |